Chronic hepatitis B: treatment. in touch magazine | Biomedicina.com.ua
Home Emergency first aid ambulance assistance mum Children - Preschoolers in touch magazine (2-5) Babies and Kids (0-2) Daily care for newborns Health Women's Health Men's Health Herbs disease and its treatment Allergy Pain Hematology Gastroenterology Diseases of bones and joints Infectious Diseases Cardiology Diseases of the ear, nose and throat
Adenopathy. Evaluation of lymph nodes Asphyxia. Types of mechanical asphyxia autolysis of tissues and organs structure of the cell structure of the stomach. Structure intestinal excretory system. Hematopoietic system Types tissue definition sex cells gunshot wound. Bruising in touch magazine of the brain histology of cell division. Sex chromatin Electric and radiation injury Embrionolohiya in touch magazine Endocrine Pathology Inflammation and lymph nodes. Oncology and lymph circulation in the body change pathological changes of body tissues in the pathology of bone and muscle tissue criminal abortion. Newborn and fetal hemorrhage. Score wounds to the body lymph node. Research lymph node Lymphomas of mature B-cell lymphoma. Leukemia Lymphocytes Lipoma. Liposarkoma Methods for assessing accessories cell morphology lymphomas. Types of Lymphoma in touch magazine Morphology bruise of the brain. Embolism various origins tumor tissue of hearing and balance. Musculoskeletal system features of cancer cells. Diagnosis of tumor pathomorphosis tumor. Cytological diagnosis. Pathomorphology tissue Derivatives skin. Digestive System Private in touch magazine histology. Nervous tissue. Causes of tumor antitumor immunity. Pathomorphosis tumor. Tumors of the larynx. Lung Cancer Tumors of the gallbladder and the duodenal papilla tumors intestine. Tumors of the liver tumors of muscle and vascular tissue tumors of soft tissue tumors of the nose and paranasal sinus tumors of the pancreas, kidney, bladder, prostate tumors and thyroid tumors of the bladder. Tumors of the vagina and vulva Tumors of the esophagus and stomach tumors in touch magazine cervical and uterine tumors Testicular in touch magazine Cancer Tumor cells of middle and inner ear development of tumor cardiovascular system. Respiratory System T-lymphoma. Types of T-lymphoma cancer Theories thermal burns. general hypothermia fibroma. Fibrosarcoma. in touch magazine Cytology Cytology tumors Ovum. Embryogenesis
Treatment depends on the rate of viral replication. According prospective controlled trials in replicative in touch magazine stage histologically proven compensated in touch magazine chronic hepatitis B with increased aminotransferase activity, in touch magazine regardless of histology effective interferon alfa n / a dose of 5 million IU / day or 10 million ME 3 times per week for 16 weeks. In 40% of cases the infection goes into the integrative stage and comes seroconversion (HBeAg disappears and there are antibodies to it), reduced morphological changes, and 10% of patients no longer detected HBsAg. If successful, the treatment is usually observed transient increase aminotransferase activity, as in acute hepatitis, perhaps this is due to the stimulation of cellular immunity and destruction of infected hepatocytes. Recurrences are rare, only 1-2% of cases. The effectiveness of interferon alpha above at the level of viral DNA in serum below 0.2 ng / ml or a significant increase in aminotransferase activity (at least to 100-200 IU / l). The probability of elimination of HBsAg during treatment above with a small duration of disease (average - about half the year). Prolonged observation showed that within 5 years after the disappearance of markers of virus replication in 60-70% of patients disappears and HBsAg, ie is no serological markers of infection.
Indications of interferon alpha given in Table. 297.4. Complications of treatment include in touch magazine flu-like syndrome, suppression of hematopoiesis, emotional disturbances (irritability, rarely - depression), autoimmune disease (eg, chronic lymphocytic thyroiditis), alopecia, rash, diarrhea, numbness and tingling in the extremities. All complications except thyroiditis, disappear with dose reduction or discontinuation of the drug.
Long-term treatment in touch magazine with glucocorticoids is not only ineffective, but also may cause harm, but in some cases they still prescribe a short course. Glucocorticoids suppress cellular immunity, activating viral replication and expression of antigen on the membrane of hepatocytes. Theoretically, after their withdrawal CD8 lymphocyte activity should recover, and they must destroy hepatocytes expressed antigen. Indeed, it increases the activity of aminotransferases and viral replication slows and can even stop. It is shown that in chronic in touch magazine hepatitis B, especially when a slight increase in aminotransferases, effective 6-week course of prednisone (60, 40 and 20 mg / day for 2 weeks) in combination with interferon alfa (5 million IU / day for 4 months). In practice, such a scheme of treatment
Home Emergency first aid ambulance assistance mum Children - Preschoolers in touch magazine (2-5) Babies and Kids (0-2) Daily care for newborns Health Women's Health Men's Health Herbs disease and its treatment Allergy Pain Hematology Gastroenterology Diseases of bones and joints Infectious Diseases Cardiology Diseases of the ear, nose and throat
Adenopathy. Evaluation of lymph nodes Asphyxia. Types of mechanical asphyxia autolysis of tissues and organs structure of the cell structure of the stomach. Structure intestinal excretory system. Hematopoietic system Types tissue definition sex cells gunshot wound. Bruising in touch magazine of the brain histology of cell division. Sex chromatin Electric and radiation injury Embrionolohiya in touch magazine Endocrine Pathology Inflammation and lymph nodes. Oncology and lymph circulation in the body change pathological changes of body tissues in the pathology of bone and muscle tissue criminal abortion. Newborn and fetal hemorrhage. Score wounds to the body lymph node. Research lymph node Lymphomas of mature B-cell lymphoma. Leukemia Lymphocytes Lipoma. Liposarkoma Methods for assessing accessories cell morphology lymphomas. Types of Lymphoma in touch magazine Morphology bruise of the brain. Embolism various origins tumor tissue of hearing and balance. Musculoskeletal system features of cancer cells. Diagnosis of tumor pathomorphosis tumor. Cytological diagnosis. Pathomorphology tissue Derivatives skin. Digestive System Private in touch magazine histology. Nervous tissue. Causes of tumor antitumor immunity. Pathomorphosis tumor. Tumors of the larynx. Lung Cancer Tumors of the gallbladder and the duodenal papilla tumors intestine. Tumors of the liver tumors of muscle and vascular tissue tumors of soft tissue tumors of the nose and paranasal sinus tumors of the pancreas, kidney, bladder, prostate tumors and thyroid tumors of the bladder. Tumors of the vagina and vulva Tumors of the esophagus and stomach tumors in touch magazine cervical and uterine tumors Testicular in touch magazine Cancer Tumor cells of middle and inner ear development of tumor cardiovascular system. Respiratory System T-lymphoma. Types of T-lymphoma cancer Theories thermal burns. general hypothermia fibroma. Fibrosarcoma. in touch magazine Cytology Cytology tumors Ovum. Embryogenesis
Treatment depends on the rate of viral replication. According prospective controlled trials in replicative in touch magazine stage histologically proven compensated in touch magazine chronic hepatitis B with increased aminotransferase activity, in touch magazine regardless of histology effective interferon alfa n / a dose of 5 million IU / day or 10 million ME 3 times per week for 16 weeks. In 40% of cases the infection goes into the integrative stage and comes seroconversion (HBeAg disappears and there are antibodies to it), reduced morphological changes, and 10% of patients no longer detected HBsAg. If successful, the treatment is usually observed transient increase aminotransferase activity, as in acute hepatitis, perhaps this is due to the stimulation of cellular immunity and destruction of infected hepatocytes. Recurrences are rare, only 1-2% of cases. The effectiveness of interferon alpha above at the level of viral DNA in serum below 0.2 ng / ml or a significant increase in aminotransferase activity (at least to 100-200 IU / l). The probability of elimination of HBsAg during treatment above with a small duration of disease (average - about half the year). Prolonged observation showed that within 5 years after the disappearance of markers of virus replication in 60-70% of patients disappears and HBsAg, ie is no serological markers of infection.
Indications of interferon alpha given in Table. 297.4. Complications of treatment include in touch magazine flu-like syndrome, suppression of hematopoiesis, emotional disturbances (irritability, rarely - depression), autoimmune disease (eg, chronic lymphocytic thyroiditis), alopecia, rash, diarrhea, numbness and tingling in the extremities. All complications except thyroiditis, disappear with dose reduction or discontinuation of the drug.
Long-term treatment in touch magazine with glucocorticoids is not only ineffective, but also may cause harm, but in some cases they still prescribe a short course. Glucocorticoids suppress cellular immunity, activating viral replication and expression of antigen on the membrane of hepatocytes. Theoretically, after their withdrawal CD8 lymphocyte activity should recover, and they must destroy hepatocytes expressed antigen. Indeed, it increases the activity of aminotransferases and viral replication slows and can even stop. It is shown that in chronic in touch magazine hepatitis B, especially when a slight increase in aminotransferases, effective 6-week course of prednisone (60, 40 and 20 mg / day for 2 weeks) in combination with interferon alfa (5 million IU / day for 4 months). In practice, such a scheme of treatment
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